It's best to target your specific symptoms. For reducing fever and relieving the prominent body aches, acetaminophen (Tylenol) or ibuprofen (Advil, Motrin) are highly effective. For congestion, a decongestant like pseudoephedrine (Sudafed) can help clear a stuffy nose. If you have a cough, look for a suppressant like dextromethorphan. Many products are combinations, but it's often safer to take single-ingredient medicines so you only treat what you have and avoid accidental overdose.