For an early, uncomplicated case of inhalation, gastrointestinal, or severe cutaneous anthrax, the first-line protocol is aggressive combination therapy. The standard is ciprofloxacin or doxycycline, plus one or two additional antibiotics (such as clindamycin, rifampin, or a penicillin) to enhance efficacy and prevent resistance. Treatment typically begins intravenously and continues for at least 60 days total, as spores can persist and germinate weeks later. Naturally occurring B. anthracis remains largely susceptible to these antibiotics, and resistance is extremely rare, though engineered resistance in a bioweapon context is a theoretical concern. Early, sustained multi-drug treatment is critical for survival.