To relieve the intense itching from chickenpox, over-the-counter options like calamine lotion (with zinc oxide) can safely soothe and dry the blisters. A lukewarm oatmeal or baking soda bath also helps calm irritation. If itching is severe, a doctor-approved oral antihistamine such as diphenhydramine can be given, especially at night. Always use gentle, fragrance-free moisturizers after bathing to prevent dryness. Avoid applying strong steroid creams, antibiotic ointments, or lotions on broken or oozing blisters, as they can trap moisture and increase infection risk. Keeping the skin clean, cool, and lightly moisturized ensures faster, itch-free healing.