Technological innovations were crucial in controlling and eradicating smallpox. The bifurcated needle, a simple yet revolutionary tool, made mass vaccination faster, cheaper, and more effective. Freeze-dried vaccines improved stability, allowing transport to remote and tropical regions without losing potency. Advances in diagnostic tools, like electron microscopy and serological tests, enabled precise identification of the variola virus, helping distinguish smallpox from similar diseases. Communication technologies also played a role, allowing rapid reporting and coordination between health teams worldwide. Together, these innovations made global vaccination campaigns efficient and reliable, leading to the complete eradication of smallpox by 1980.