Recognizing the early signs of Post-Polio Syndrome (PPS) is vital for effective management. The most common initial symptoms include new muscle weakness in limbs previously affected by polio, as well as in those that seemed unaffected. This is often accompanied by profound and debilitating fatigue that is not relieved by sleep. Additionally, individuals may experience new pain in muscles and joints and notice a gradual shrinking or atrophy of muscle mass. Identifying these signs early allows for timely intervention to slow progression and manage symptoms.