You have perfectly identified the core early warning signs of Post-Polio Syndrome. The emergence of new, progressive muscle weakness and overwhelming fatigue that is not relieved by rest are the most hallmark symptoms. This is often accompanied by persistent muscle and joint pain, and visible shrinking (atrophy) of muscles. Recognizing this specific cluster of symptoms is crucial because it differentiates PPS from general aging or other conditions. Early diagnosis allows individuals to immediately implement essential management strategies, the most important of which is lifestyle modification focused on energy conservation. This includes scheduled rest periods, using assistive devices, and avoiding overexertion to prevent accelerating the loss of motor neurons. This proactive approach is vital for preserving existing function, managing pain, and maintaining quality of life over the long term.