For managing pain and fatigue in Post-Polio Syndrome (PPS), a combination of energy conservation and targeted exercise is most effective. This includes "pacing" activities by breaking them into small segments with rest breaks to avoid exhaustion. Using assistive devices like canes or ankle-foot orthotics (AFOs) reduces strain on muscles and joints, thereby decreasing pain. For exercise, gentle, non-weight-bearing activities like swimming or water aerobics in a warm pool are highly beneficial as they build strength without causing fatigue. Crucially, incorporating scheduled rest periods into each day and making lifestyle modifications, such as reorganizing your home to minimize stair climbing, can make a profound difference in preserving energy and maintaining quality of life.