Clinical depression, or major depressive disorder, is a serious mental health condition characterized by a persistently low or depressed mood and loss of interest in activities for at least two weeks. Emotional symptoms include sadness, hopelessness, irritability, low self-esteem, and thoughts of suicide, while physical symptoms can involve changes in appetite, sleep disturbances, fatigue, aches, and slowed movements. Evidence-based treatments typically combine psychotherapy — such as cognitive behavioral therapy — and antidepressant medications. For severe cases, electroconvulsive therapy may be recommended. Support for your friend involves encouraging professional help, showing empathy, listening without judgment, and helping maintain routines and social connections. Mental health professionals like psychiatrists and therapists can be found through local clinics, hospitals, and trusted online platforms. Therapy and medication costs vary widely by location and provider, but many regions offer free or subsidized counseling services. Reputable mental health hospitals include academic medical centers and specialized psychiatric clinics. Always ensure your friend’s safety by recognizing warning signs of suicide and seeking emergency help if needed. Encouraging ongoing communication and patience is key to supporting someone with clinical depression.