The key difference is that Scarlet Fever occurs when certain strains of Group A Streptococcus produce a toxin called erythrogenic toxin, which triggers the characteristic red, sandpaper-like rash. Regular strep throat is caused by the same bacteria but does not produce this toxin, so no rash appears. Essentially, it’s not a completely different strain for every case, but rather a toxin-mediated reaction in susceptible individuals, which is why some people with strep develop Scarlet Fever while others do not.