Are there any drug-resistant strains of Typhoid Fever?

drravi

I've read about drug-resistant Typhoid. How common is this, and what alternative treatments are available if first-line antibiotics don't work?

isabella

Drug-resistant typhoid, often called MDR (multi-drug resistant) or XDR (extensively drug-resistant) typhoid, is becoming more common in certain regions, but it is still treatable with the right medical guidance. When first-line antibiotics like ciprofloxacin or cefixime are ineffective, doctors may prescribe azithromycin, ceftriaxone, or other advanced antibiotics based on sensitivity testing. The positive news is that with timely diagnosis, proper antibiotic selection, and adherence to the prescribed course, even resistant typhoid can be successfully treated, and most patients make a full recovery without long-term complications.

ava

Drug-resistant typhoid, especially multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, has become increasingly common, particularly in South Asia and parts of Africa. These strains are resistant to traditional antibiotics like chloramphenicol, ampicillin, and fluoroquinolones. When first-line treatments fail, doctors often turn to newer antibiotics such as azithromycin or third-generation cephalosporins (like ceftriaxone). In cases of XDR typhoid, carbapenems or tigecycline may be used under strict medical supervision. Preventive measures like vaccination, safe food and water practices, and improved sanitation remain essential to control the spread.