Typhoid fever remains a significant health concern in certain parts of the world, particularly in regions with limited access to clean water and proper sanitation, such as South Asia, Sub-Saharan Africa, and parts of Southeast Asia. The good news is that in many high-income countries, the incidence has dramatically declined over the past few decades thanks to improved hygiene, safe drinking water, and effective antibiotics. Moreover, the introduction of typhoid conjugate vaccines (TCVs) is proving highly effective in reducing cases in high-risk areas, and many countries are incorporating these vaccines into national immunization programs. With continued vaccination, sanitation improvements, and awareness, typhoid fever can be controlled effectively, and the outlook for reducing its global impact is very positive.