Paratyphoid fever is treated with antibiotics that target Salmonella Paratyphi, and the most commonly prescribed drugs today are azithromycin and ceftriaxone, both of which are effective against most current strains. In the past, antibiotics like chloramphenicol, ampicillin, and ciprofloxacin were widely used, but growing antibiotic resistance has made them less reliable. In some regions where resistant or extensively drug-resistant strains have emerged, doctors may use stronger antibiotics such as carbapenems under hospital supervision. Because resistance patterns vary by location, doctors usually recommend doing a culture and sensitivity test to choose the most effective antibiotic. Early and appropriate treatment helps prevent complications and reduces the risk of spreading the infection.