Yes, the rabies vaccine can cause some mild and temporary side effects, which are generally normal. The most common are pain, redness, or swelling at the injection site, along with mild fever, headache, fatigue, or muscle aches. These symptoms usually go away within a few days. Serious allergic reactions, such as hives, breathing difficulty, or facial swelling, are extremely rare. If you experience any severe reaction after vaccination, seek medical attention immediately. Overall, the vaccine is very safe — and the small risk of side effects is far outweighed by its protection against a nearly fatal disease.