The rabies vaccine provides long-lasting protection, but the duration depends on your level of exposure risk. For most people, immunity lasts about 2 to 3 years after the initial series. Those who work in high-risk environments — such as veterinarians, animal handlers, or travelers to endemic areas — should get booster doses every 3 years, or have their antibody levels checked to decide if a booster is needed. For the general public, once post-exposure treatment is completed, no routine boosters are required unless another potential rabies exposure occurs.