Yellow Fever is confirmed mainly with blood tests: early in illness, RT-PCR can detect viral RNA in the first few days, while later testing relies on IgM antibody tests (ELISA) with confirmatory neutralization tests (PRNT) to avoid false positives; routine blood work often shows low platelets and liver enzyme elevation, which supports suspicion but isn’t diagnostic—results can take hours to a few days depending on the test and lab capacity, and misdiagnosis is common because symptoms overlap with malaria, dengue, viral hepatitis, and sepsis, making travel history and correct timing of tests critical for an accurate diagnosis.