The Yellow Fever vaccine is very effective at preventing the disease, offering more than 99% protection after a single dose. This vaccine typically provides lifetime immunity for most people, and no boosters are required. According to the World Health Organization (WHO), a single shot is sufficient for long-lasting protection. However, certain high-risk groups, such as those with weakened immune systems or specific health conditions, may need additional doses or vaccination before future exposure. If you're traveling to or living in an area where Yellow Fever is common, getting vaccinated is essential, as it is the most reliable way to prevent the disease.